The 1958 National Child Development Study (NCDS) and Millennium Cohort Study (MCS) samples have been extensively genotyped. Genotyping of the 1970 British Cohort Study (BCS70) is ongoing.
We have collected biological samples from three of our studies: NCDS (blood, saliva), BCS70 (blood) and MCS (saliva, teeth). We welcome applications for further use of these samples.
Find out how to apply for access to CLS genetic data and/or biological samples.
Details of the specific measures and data governance are shown below.
NCDS has collected whole blood and saliva from cohort members. Original samples, aliquots and residues are held at the University of Bristol, who are the custodians of the CLS biological samples.
DNA was extracted from whole blood and there is also a transformed lymphocytes collection. Both of these collections have been extensively genotyped. The transformed lymphocyte collection allows for further DNA extraction, whilst the whole blood derived DNA collection is a finite resource.
We have four main types of genomic data available for research purposes:
NCDS genomic data is available via different routes based on the type of data and if it is required to be linked to NCDS survey data. The various options are outlined below:
1) For access to Genome Wide (GW) genotyping data in isolation (i.e. not linked to any other NCDS data), please apply directly to the European Genome-phenome Archive (EGA), which hosts a copy of these data. The GW data release from the EGA is managed by the Wellcome Trust Sanger Data Access Committee (Sanger DAC), at firstname.lastname@example.org.
2) Access to Genome Wide (GW) genotyping data linked to any other NCDS phenotypic or genomic data can be requested via the CLS Data Access Committee.
3) NCDS biological samples and the rest of the NCDS genomic data (imputed, epigenetics and sequencing) can also be requested via the CLS Data Access Committee.
The 2016-17 Biomedical Survey for BCS70 (Age 46) collected whole blood samples from cohort members. Original samples are held at the University of Bristol.
CLS will commission the genotyping of the DNA. Access to samples and genetic data can requested via the CLS Data Access Committee.
Milk teeth were collected from age 7 (MCS4) onwards and are currently stored at the Institute for Child Health.
In 2015-6, the Age 14 Sweep (MCS6) collected saliva from cohort members and both natural resident parents. DNA was extracted from the saliva samples. Unlike the NCDS transformed lymphocytes collection, this is non-renewable. University of Bristol are the custodians for these biological samples.
The genetic data collection and genetic data generated are described in the CLS working paper, Collection of DNA samples and genetic data at scale in the UK Millennium Cohort Study.
MCS biological samples, data arising from milk teeth, and MCS genetic data can be requested via the CLS Data Access Committee.