Genetic data and biological samples

The 1958 National Child Development Study (NCDS) and Millennium Cohort Study (MCS) samples have been extensively genotyped. Genotyping of the 1970 British Cohort Study (BCS70) is ongoing.

We have collected biological samples from three of our studies: NCDS (blood, saliva), BCS70 (blood) and MCS (saliva, teeth). We welcome applications for further use of these samples.

Find out how to apply for access to CLS genetic data and/or biological samples.

Details of the specific measures and data governance are shown below.

 

1958 National Child Development Study (NCDS)

The 2002/3 Biomedical Survey for NCDS collected whole blood and saliva from cohort members. CLS is the custodian of these samples, and the processing and storage of both original aliquots and residues is contracted to the University of Bristol (Bristol Bioresource Laboratories, Population Health Sciences, Bristol Medical School).

DNA was extracted from whole blood and there is also a transformed lymphocytes collection. Both of these collections have been extensively genotyped. The transformed lymphocyte collection allows for further DNA extraction, whilst the whole blood derived DNA collection is a finite resource.

We have four main types of genomic data available for research purposes:

NCDS genomic data is available via different routes based on the type of data and if it is required to be linked to NCDS survey data. The various options are outlined below:

1)     For access to Genome Wide (GW) genotyping data only (i.e. not linked to any other NCDS data), please apply directly to the European Genome-phenome Archive (EGA). The GW data release approval is managed by the Wellcome Trust Sanger Data Access Committee (Sanger DAC), at datasharing@sanger.ac.uk.

2)    Access to Genome Wide (GW) genotyping data linked to any other NCDS phenotypic or genomic data can be requested via the CLS Data Access Committee.

3)    NCDS biological samples and the rest of the NCDS genomic data (imputed, epigenetics and sequencing) can also be requested via the CLS Data Access Committee.

 

1970 British Cohort Study (BCS70)

The 2016-17 Biomedical Survey for BCS70 (Age 46) collected whole blood samples from cohort members. Original samples are held at the University of Bristol.

CLS will commission the genotyping of the BCS70 DNA. Access to samples and genetic data will be available for request via the CLS DAC.

Next Steps

Saliva samples will be collected from Next Steps participants during the Age 32 Survey. DNA will be extracted from the samples and genotyped. CLS will the custodian of these samples, and their processing and storage will be managed by the University of Bristol (Bioresource Laboratories, Population Health Sciences, Bristol Medical School).

Millennium Cohort Study (MCS)

Oral fluid was collected at age 3 (MCS2). All oral fluid samples are depleted and residues were destroyed. Data arising from the assay are available at the UK Data Service.

Milk teeth were collected from age 7 (MCS4) onwards, and these are stored at the UCL Institute for Child Health (ICH). Access to these milk teeth and related research data can be requested via the CLS DAC.

In 2015-16, the age 14 sweep (MCS6) collected saliva from cohort members and both natural parents. DNA has been extracted from the saliva samples and genotyped. Unlike the NCDS transformed lymphocytes collection, this is non-renewable. CLS is the custodian of these samples, and their processing and storage has been contracted to the University of Bristol (Bristol Bioresource Laboratories, Population Health Sciences, Bristol Medical School).

Please see the Millennium Cohort Study genetics information for details of the genetic data available for research purposes, which includes genotype data, imputed data, and the Illumina GenomeStudio Final Report. The genetic data collection and genetic data generated are described in the CLS working paper, Collection of DNA samples and genetic data at scale in the UK Millennium Cohort Study.

MCS genetic data can be requested via the CLS Data Access Committee.

 

 

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Centre for Longitudinal Studies
UCL Social Research Institute

20 Bedford Way
London WC1H 0AL

Email: clsfeedback@ucl.ac.uk