Genetic data and biological samples

Genotyped data and biological samples are available from all of CLS’s adult cohort studies: the 1958 National Child Development Study (NCDS), the 1970 British Cohort Study (BCS70), Next Steps, and the Millennium Cohort Study (MCS).

Apply to access the genetic data or stored biological samples for research purposes

Genetic data or access to stored biological samples can be requested via the CLS Data Access Committee. For specific information on the genetic data we have for each cohort and the quality control measures taken, please see our GitHub website (external site). In addition, the European Genome-Phenome Archive (EGA) provides access to NCDS genetic data (not linked to survey data) and MCS exome data.

The following stored biological samples are available for application:

  • blood (NCDS and BCS70)
  • lymphocyte (NCDS)
  • saliva (Next Steps and MCS).

Milk teeth were collected in MCS but are not yet available for application (further information is forthcoming). MCS2 (age 3) oral fluid was collected at age 3 (MCS2) but all samples are depleted and residues were destroyed.

Cohort study Source(s) Sweep collected Data type Visit the CLS genetic Github
NCDS
(born 1958)
Blood (+lymphocytes), saliva Age 44 Biomedical Sweep (2002-03) Genetic, exome, epigenetic, proteomic NCDS Github
BCS70
(born 1970)
Blood Age 46 Biomedical Sweep (2016-18) Genetic, epigenetic BCS70 Github
Next Steps
(born 1989-90)
Saliva Age 32 Sweep (2022-23) Genetic Next Steps Github
MCS
(born 2000-02)
Saliva Age 14 Sweep (2015-16) Genetic, exome MCS Github

Visit the CLS Genomics Github for full details on resources available

Resource profile

Shireby, G., Morris, T.T., Wong, A., Chaturvedi, N., Ploubidis, G.B., Fitzsimmons, E., Goodman, A., Sanchez-Galvez, A., Davies, N.M., Wright, L., Bann, D. (2024)
Data Resource Profile: Genomic Data in Multiple British Birth Cohorts (1946-2001)—Health, Social, and Environmental Data from Birth to Old Age
medRxiv
Read the full paper

Watch again: Genetics and epigenetics in the CLS cohort studies

Contact us

Centre for Longitudinal Studies
UCL Social Research Institute

20 Bedford Way
London WC1H 0AL

Email: clsdata@ucl.ac.uk

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