Polygenic indices in four national longitudinal cohorts user guide

This document describes the process by which polygenic indexes (PGIs) for 44 traits have been constructed in four UK longitudinal cohort studies: 1958 National Child Development Study (NCDS), 1970 British Cohort Study (BCS70), Millennium Cohort Study (MCS) and Next Steps.

Author: Tim T Morris, Gemma Shireby, Liam Wright, Aida Sanchez-Galvez, Georg Otto, David Bann. Date published: 24 September 2025
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